Retinoids in oncology

Publisher: Springer in Berlin, New York

Written in English
Published: Pages: 115 Downloads: 256
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  • Retinoids -- Therapeutic use -- Congresses.,
  • Cancer -- Chemotherapy -- Congresses.,
  • Neoplasms -- therapy -- congresses.,
  • Neoplasms -- prevention & control -- congresses.,
  • Retinoids -- therapeutic use -- congresses.,
  • Retinoids -- pharmacology -- congresses.

Edition Notes

StatementL. Degos, D.R. Parkinson, eds.
SeriesEso monographs, Monographs (European school of Oncology)
ContributionsDegos, Laurent., Parkinson, D. R. 1950-, European School of Oncology.
LC ClassificationsRC280.V57 R48 1995
The Physical Object
Pagination115 p. :
Number of Pages115
ID Numbers
Open LibraryOL782313M
ISBN 103540591818
LC Control Number95014259

Summary This volume contains papers presented at the Conference on Retinoids: New Trends in Research and Clinical Applications, held in in Palermo, Italy, describing the latest research findings on biochemistry, nutrition, molecular and cell biology and developmental biology, as well as the pharmacology and the therapeutic use of vitamin A and its congeners.;Written by .   CT and MR have changed the way oncologic disease is diagnosed and managed. This book addresses the expanded role of CT and MR in oncologic disease. The correlation of clinical and imaging features makes this a useful reference for anyone working with oncology patients. There is no other comparable book in the field. Mary A. TurnerAuthor: Didier Buthiau.   All classes of Retinoids: basic sructure of Vit A with modifications 1 st gen. Retinoids 2 nd gen. Retinoids 3 rd gen Retinoids Change of Polar end group & polyene side chain Replacing cyclic end group of Vit A with subsituted & non subsituted ring systems. Cyclization of polyene side chain. Vitamin A and retinoids: from nutrition to pharmacotherapy in dermatology and oncology. Author(s): Bollag, W. Journal article: Lancet Vol.1 pp refCited by:

is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in , this collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters.   ATRA is the only example of a clinically useful cyto-differentiating agent in oncology [3, 4], having changed the natural history of acute promyelocytic leukemia, a rare form of acute myelogenous leukemia [].This along with promising results obtained in preclinical models has spurred interest in the use of ATRA and natural (9-cis and cis retinoic acid) or synthetic Cited by: retinoids: (ret'i-noydz), A class of keratolytic drugs derived from retinoic acid and used for treatment of severe acne and psoriasis.   Nutritional oncology is an increasingly active interdisciplinary field where cancer is investigated as both a systemic and local disease originating with the changes in the genome and progressing through a multi-step process which may be influenced at many points in its natural history by nutritional factors that could impact the prevention of cancer, the quality of life of 4/5(2).

Retinoids are lipophilic compounds derived from vitamin A, which have been extensively studied in cancer prevention and therapy. In pediatric oncology, . Title: Retinoids as Differentiating Agents in Oncology: A Network of Interactions with Intracellular Pathways as the Basis for Rational Therapeutic Combinations VOLUME: 13 ISSUE: 13 Author(s):Enrico Garattini, Maurizio Gianni and Mineko Terao Affiliation:Istituto di Ricerche Farmacologiche “Mario Negri”, via Erit Milano, Italy. Oncology Comments Off on Retinoids in Oncology. lipoxins, isoprostanes, hepoxilins, hydroxy acids, epoxy and hydroxy fatty acids. This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. In addition, recent evidence over the last seven. Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic retinoid derivative. Retinoids are substances related to vitamin A. It has been investigated for potential use in the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, psoriasis, and has been found to also slow the production and accumulation of a toxin that leads to vision loss in CAS Number:

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Retinoids in Oncology - CRC Press Book This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous di.

Book Description. This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease Retinoids in oncology book, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant.

Retinoids in Oncology (ESO Monographs) Softcover reprint of the original 1st ed. Edition. by Laurent Degos (Author) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're Retinoids in oncology book exactly the right version or edition of a book. Author: Laurent Degos.

Recent developments with respect to the biology and clinical use of retinoids in cancer therapy and prevention are comprehensively covered by experts in.

Recent developments with respect to the biology and clinical use of retinoids in cancer therapy and prevention are comprehensively covered by experts in this new field. Newer aspects of molecular mechanisms of retinoid effects, the cellular biology and the developmental effects of these compounds.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle.

Retinoids in oncology. [Waun Ki Hong; Reuben Lotan;] of growth and differentiation by combined retinoids and cytokines in cancer / Werner Bollag and Richard Peck --Retinoids in experimental oncology / Richard C.

Moon --Clinical toxicity of retinoids / Isaiah W. Dimery --Retinoids in leukemia and myelodysplastic Book\/a>, schema. Synthetic retinoids is the most effective treatment for Darier's disease and certain other disorders of keratinization. The use of synthetic retinoids in cancer prevention and therapy for both cutaneous and internal tumors is potentially the most significant clinical use of these drugs.

Summary. Retinoids are a class of compounds structurally related to vitamin A. In preclinical studies, all-trans retinoic acid (tretinoin), cis retinoic acid (isotretinoin) and the aromatic retinoids etretinate and acitretin have preventive and therapeutic effects on carcinogen-induced premalignant and malignant by: Combination therapy involving the retinoids and other chemoprevention agents is an attractive pharmacological strategy.

Indeed, retinoids have already been shown to cooperate with interferon‐α‐2a in treatment of squamous cell cancers of the skin and cervix, as well as in kidney cancer [81‐83]. Perhaps these or other combination regimens Cited by: The results presented by Bosch and colleagues [] in the previous issue of Breast Cancer Research are a major step towards the identification of the critical determinants controlling the responses of breast tumor cells to alltrans-retinoic acid (ATRA), the prototype of retinoids, a promising class of anti-cancer authors demonstrate that the two retinoid nuclear Cited by: Clinical evaluation of retinoids, especially newer synthetic retinoids in combination with molecular targeted and epigenetic therapy remains an active area of investigation in oncology.", keywords = "Promyelocytic leukemia, Retinoic acid receptors, Retinoid x retinoids, Retinoids".

This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book:. This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology.

Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of. DOI: /JCO Journal of Clinical Oncology - published online before print Septem PMID: Cited by: This book should prove to be an extraordinary reference text for students, physicians and oncologists.

Indexed in: Book Citation Index, Science Edition, Scopus, BIOSIS Previews, EBSCO. eBook: US $79 Special Offer: US $ Printed Copy: US $ Library License: US $Cited by: 2. Retinoids are a class of compounds structurally related to vitamin A. More than retinoids have been synthesized and tested for biological activity.

Nine of these were evaluated as agents for cancer chemoprevention by an international group of experts at a meeting held in March /5(1). Topical retinoids provide a beneficial, novel way of treating a plethora of dermatologic disorders, in view of their ability to address.

Retinoids, retinoic acid receptors, and cancer. Tang XH(1), Gudas LJ. Author information: (1)Department of Pharmacology, Weill Cornell Medical College, New York, New YorkUSA. Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem by: The use of retinoids in clinical oncology and particularly in chemoprevention poses specific problems of tolerability, whether the agents are used singly or in combination with other anticancer by: 3.

The retinoids are a class of chemical compounds that are vitamers of vitamin A or are chemically related to it. Retinoids have found use in medicine where they regulate epithelial cell growth.

Retinoids have many important functions throughout the body including roles in vision, regulation of cell proliferation and differentiation, growth of bone tissue, immune function, and activation.

Retinoids currently play a limited role in cancer treatment and prevention despite potential in physiological pathways. Toxicity represents the main limitation to the prolonged use of retinoids.

Retinoids are natural and artificial compounds that are similar in structure or biological. Retinoids deliver a plethora of benefits to individuals of various ages. In addition to the FDA-approved indications, topical retinoids have numerous off.

PURPOSE Recent reports of the dramatic antitumor effect of all-trans retinoic acid (RA) in patients with acute promyelocytic leukemia (APL) have generated renewed enthusiasm for clinical studies of retinoids for oncologic therapeutic indications.

Here we provide an overview of relevant aspects of retinoid physiology and molecular biology, review preclinical studies Cited by: The final three chapters deal with practical applications of retinoids in the field of experimental and clinical oncology and dermatology. The following chapters are included in this book: - T h e synthetic chemistry of retinoids.

--Analytical methods. Retinoids are important modulators of cell growth, differentiation, and proliferation. 9cUAB30, 9cUAB, and 9cUAB are three novel retinoid compounds that show cytotoxic effects in other malignancies.

We evaluated these novel retinoids in combination with chemotherapy against ovarian cancer stem cells (CSCs) in vitro and in an ex vivo by: In the future' the decade of the s will likely be viewed as a Golden Age for retinoid research.

There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop­ mental processes was first broadly recognized in the late : Hardcover.

The retinoid literature is voluminous, and there are a number of authoritative multiauthor reviews of the basic science (volumes and of Methods in Enzymology, published in ) and clinical aspects (Retinoids: 10 Years On, New York, NY, S Karger AG, ) of retinoid ore, I picked up Korem's book, which uniquely addresses the Cited by: title = "Advances in the Use of Retinoids in Cancer Therapy and Prevention", abstract = "Retinoids are natural and synthetic derivatives of vitamin A.

The anticancer properties of retinoids have long been investigated in the preclinical, epidemiological and clinical : Michael J.

Spinella, Sarah J. Freemantle, Ethan Dmitrovsky. molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects, Journal of Dermatological Treatment, DOI: /. The impact of the retinoids in clinical practice has primarily been in dermatology.

When Dr Werner Bollag began his basic research and screening programme in the early 's, the expectation was that the retinoids would have a major impact on Brand: Springer Netherlands.The Retinoids: Biology, Biochemistry, and Diseaseprovides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy.

Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin .Retinol is a form of vitamin A found in animal products, such as livers, kidneys, eggs, and dairy products.

Retinol and other forms of vitamin A are necessary for a healthy diet and help in the function of your vision, skin cellular growth, immune function, and the .